To facilitate in the development and testing of novel liposome formulations of antimicrobial agents to be used in treating fungal and bacterial infections of plants which are commercially important to California's economy (e.g., grapes and orchids).
Project Number: 01-04-029
Funding Round: 2 (2000-2001)
Research Focus Area: Biotechnology
ARI Member Campus: California State Polytechnic University, Pomona
Director: Adler-Moore, Jill
To develop a non-toxic system for treating fungal plant infections caused by pathogens such as Fusarium, Phytophthora, and Botrytis. The approach involves forumulation of hydrophobic antifungal agents, e.g., nystatin, into small, water soluble,unilamellar liposomes and applying it to plants through the leaves, stems or roots.
Project Number: 06-04-125
Funding Round: 7 (2005-2006)
Research Focus Area: Biotechnology
ARI Member Campus: California State Polytechnic University, Pomona
Director: Adler-Moore, Jill
To test combination vaccine regimens against two strains of influenza virus, one of which is H5NI, or the avian or bird flu. The work will feature the immunization of mice with liposomes carrying experimental M2e protein in bacteria. Successful trials could provide an alternative, effective method for producing a broadly protective influenza virus vaccine.
Project Number: 06-04-141
Funding Round: 7 (2005-2006)
Research Focus Area: Biotechnology
ARI Member Campus: California State Polytechnic University, Pomona
Director: Adler-Moore, Jill
1. To develop the methods for scaling-up Influenza M2e liposomes from 2ml to 20ml (40 doses to 400 doses).
2. To compare the efficacy of influenza M2e liposomes prepared by scaled-up vs probe sonication methods in the mouse influenza infection model.
Project Number: 07-04-152
Funding Round: 8 (2006-2007)
Research Focus Area: Biotechnology
ARI Member Campus: California State Polytechnic University, Pomona
Director: Adler-Moore, Jill
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